Search on: CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4 
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Descriptor English:   Cyclic Nucleotide Phosphodiesterases, Type 4 
Descriptor Spanish:   fosfodiesterasas de nucleótidos cíclicos tipo 4 
Descriptor Portuguese:   Nucleotídeo Cíclico Fosfodiesterase do Tipo 4 
Synonyms English:   Cyclic Nucleotide Phosphodiesterase PDE4 Family
Cyclic Nucleotide Phosphodiesterases, Type 4A
Cyclic Nucleotide Phosphodiesterases, Type 4A5
Cyclic Nucleotide Phosphodiesterases, Type 4B
Cyclic Nucleotide Phosphodiesterases, Type 4C
Cyclic Nucleotide Phosphodiesterases, Type 4D
Cyclic Nucleotide Phosphodiesterases, Type 4D3
PDE4 Phosphodiesterases
PDE4D3 Phosphodiesterase
Phosphodiesterase 4
Phosphodiesterase 4A
Phosphodiesterase 4A5, cAMP-Specific
Phosphodiesterase 4B
Phosphodiesterase 4C
Phosphodiesterase 4D
Phosphodiesterase IV
Phosphodiesterase, PDE4D3
Phosphodiesterase-4
Phosphodiesterases, PDE4
Type 4 Cyclic Nucleotide Phosphodiesterase
cAMP Specific Phosphodiesterase 4A5
cAMP-Specific Phosphodiesterase 4A5  
Tree Number:   D08.811.277.352.640.150.400
D12.644.360.008.400
D12.776.476.008.400
Definition English:   A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL-MEDIATED IMMUNITY. The enzyme family includes over twenty different variants that occur due to multiple ALTERNATIVE SPLICING of the mRNA of at least four different genes. 
Entry Combination - descr/qualif English:   Cyclic Nucleotide Phosphodiesterases, Type 4/antagonists & inhibitors use Phosphodiesterase 4 Inhibitors
 
History Note English:   2008(1981) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   52679 
Unique Identifier:   D054703 

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